INTRODUCTION Show
It is the policy of Northern Michigan University (NMU) to establish and maintain proper measures to ensure the appropriate, humane, and ethical care and use of animals involved in research and research training activities conducted or supported by NMU. This Policy complies with the Animal Welfare Act, the Animal Welfare Act Regulations and the Public Health Service Policy on Humane Care and Use of Laboratory Animals. In accordance with these policies and regulations, the care and use of animals at NMU are consistent with the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research and Training, the Guide for the Care and Use of Laboratory Animals, and the recommendations of the American Veterinary Medical Association. PURPOSE The Institutional Animal Care and Use Committee (IACUC) represents society’s concerns regarding the welfare of animals used in activities associated with NMU. This Committee ensures the appropriate care and use of animals used in research, research training, biological testing, experimentation, teaching, and in breeding colonies that supply animals for these purposes. This Committee reviews NMU’s program of animal care and use to ensure animal health and well-being. NMU’s program includes administrative policies and procedures for: (1) IACUC organization, membership, and procedures; To this end, the IACUC APPLICABILITY These policies are applicable to studies, or components of studies, performed by NMU personnel in connection with his/her NMU responsibilities and/or using NMU property, resources, funds, or the name of NMU is being used in applying for funds (intra or extramural). Applicability of these policies will be deferred to those of another institution when the animals are owned or under legal responsibility of that institution, unless the study is funded by NMU. These policies are not applicable to whole or parts of dead animals obtained commercially or found in nature (e.g., animal tissues, fluids, organs, eggs, embryos, and fetuses) or as a byproduct of another approved research project. RESPONSIBILITIES United States Department of Agriculture (USDA): The USDA interprets and enforces compliance of institutional animal care and use specified by the Animal Welfare Act and Animal Welfare Act Regulations. USDA-regulated species are defined in the Animal Welfare Act. According to the Animal Welfare Act, an “Animal means any live or dead dog, cat, nonhuman primate, guinea pig, hamster, rabbit, or any other warmblooded animal, which is being used, or is intended for use for research, teaching, testing, experimentation, or exhibition purposes, or as a pet. This term excludes: Birds, rats of the genus Rattus and mice of the genus Mus bred for use in research, and horses not used for research purposes and other farm animals, such as, but not limited to livestock or poultry, used or intended for use as food or fiber, or livestock or poultry used or intended for use for improving animal nutrition, breeding, management, or production efficiency, or for improving the quality of food or fiber. With respect to a dog, the term means all dogs, including those used for hunting, security, or breeding purposes”. NMU is required by the USDA to conduct semi-annual animal facility and program evaluations and to submit to the USDA an annual report that describes minor or major discrepancies found in the animal facility and program evaluations and a census of USDA-regulated animals used during the last annual reporting period. The USDA performs unannounced site visits to NMU that occur at least once annually. Office of Laboratory Animal Care (OLAW): The OLAW interprets and enforces compliance of institutional animal care and use of PHS-funded or -assured animals as specified by the Public U.S. Government Principles for the Utilization and Care of Vertebrate animals Used in Testing, Research, and Training: NMU is also expected to use vertebrate animals in abidance with the nine U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research and Training. “The development of knowledge necessary for the improvement of the health and well being of humans as well as other animals requires in vivo experimentation with a wide variety of animal species. Whenever U.S. Government agencies develop requirements for testing, research, or training procedures involving the use of vertebrate animals, the following principles shall be considered; and whenever these agencies actually perform or sponsor such procedures, the responsible institutional officer shall ensure that these principles are adhered to:
NMU Institutional Animal Care and Use Committee (IACUC): The NMU IACUC oversees the implementation of all applicable federal regulations and policies, as described above, in the care and use of all vertebrate animals (cold- and warm-blooded) associated with NMU research, training, and biological testing activities. The IACUC shall:
FREQUENCY OF MEETINGS IACUC MEMBERSHIP Composition of the IACUC IACUC Chairperson Responsibilities: The IACUC Chair has the responsibility for overseeing the coordination and implementation of effective, efficient systems for protocol review and program review by the IACUC in compliance with the PHS policy and the AWA. Specifically the Chair should:
Attending Veterinarian Responsibilities: The role of the IACUC Attending Veterinarian is to:
Non-Scientist Responsibilities: The role of the Non-Scientist member is to:
Scientist Responsibilities: The role of the Scientist member is to:
Non-affiliated Member Responsibilities: The role of the Non-Affiliated member is to:
Institutional Official Responsibilities: The role of the Institutional Official:
Reporting structure The lines of authority and responsibility for administering the program and ensuring compliance with this Policy at NMU, as described in the most current PHS Assurance, are shown below. The Institutional Officer at NMU is the Dean of Graduate Studies and Research. Dean, Graduate Studies & Research ACCESS TO ANIMAL FACILITIES OCCUPATIONAL HEALTH AND SAFETY 1. Professional staff who conduct and support research programs that involve hazardous biological, chemical, or physical agents (including ionizing and nonionizing radiation) should be qualified to
assess dangers associated with the programs and to select safeguards appropriate to the risks; Risk of Zoonoses DISASTER PLANNING The requirement for institutional disaster planning is found in the Guide (p. 46) which states “A disaster plan that takes into account both personnel and animals should be prepared as part of the overall safety plan for the animal facility.” The purpose of this plan is to document an effective preparation and response strategy for emergencies that may result in an inability to maintain normal conditions in animal facilities and/or an inability of personnel to reach an animal facility, thus potentially threatening the health and welfare of animals. All personnel working with animals in NMU facilities are strongly encouraged to read the entire disaster plan carefully. List of Important Items: Emergency information: Contact information is posted near the main entrance to the animal facilities. Type of Emergency or Disaster:
Categories and Levels * Natural disasters & emergencies (e.g., earthquake, major storms, flooding), Critical Functions: As far as possible, critical animal facility specific functions and systems should be maintained:
* Air temperature surrounding the animals should remain within a normal room temperature range. Preparations for Emergencies Utility Failures The most common facility malfunctions that impact the laboratory animals are utility failures such as malfunction of the heating, ventilation, and air conditioning (HVAC) system and power outages. Response Actions: * Monday through Friday workday: Call Operations and Maintenance (phone # On Campus 2292, Off Campus 227-2292) Major Storms If a major storm occurs when bedding changes and full cage washes are scheduled, personnel who are able to make it to work should perform daily health checks in all animal rooms first. If time allows AFTER daily health checks have been done, then check food levels, topping as necessary and do the scheduled bedding changes as time allows. If the entire room cannot be completed, required daily health checks should be conducted on remaining animals and note where the bedding changes or full cage washes were stopped. Cage changing should be continued on the next day, or sooner if weather conditions improve. Fire * Notify the Fire Department immediately (911) Animal Activist Activities Response Actions: * Remain calm. Bomb Threat, Bomb or Suspicious Item Found After the call has ended, immediately call NMU Public Safety ( On Campus 2151, Off Campus 227-2151). ASSUME THAT BOMB THREATS ARE REAL. Check mail and packages for anything that appears out of place, such as unusual packaging, lack of return address, or signs of stains or leakage on the package. Carefully survey all mail after a bomb threat has been received by phone, note, or e-mail. Note any package, foreign object, or odd device. Building evacuation may be necessary after a bomb threat or the finding of a suspicious package or item. Evacuation should proceed along established fire evacuation routes, and do not attempt to evacuate any animals. Response Actions- Bomb Threat by Phone: * Remain calm Response Actions- Suspected Bomb or Suspicious Item Found: * If you see a package or foreign object in an unusual place, leave it alone. Do not touch it. Response Actions - Bomb Threat Evacuation: * Leave the building immediately using established fire evacuation routes and do not evacuate any animals. ANIMAL CARE AND USE APPLICATIONS Approval of an NMU Animal Care and Use Application is required before conducting any procedures for research or research training procedures on vertebrate animals at NMU, unless the animal use qualifies for an Exemption (see below), based upon applicability of the NMU IACUC policies or other reasons listed in the Exemption Request, pending approval of the IACUC Chair. For animals used strictly for breeding purposes (i.e., an animal colony), an Animal Colony Application must be submitted in place of the Animal Care and Use Application. All sections in the Animal Care and Use Application, the Animal Colony Application, and the Exception form must be written at a level understandable by laypersons, which is generally defined as an eighth grade reading level. Animal Care and Use Applications have the following components: Forms Due Dates for Animal Care and Use Applications USDA B and C categories: These applications may be submitted any time and will be reviewed using the Designated Member Review system within 2 weeks of receipt of the application. However, all applications are subject to potential review in Full Committee. USDA D and E categories: Due two weeks prior to the next scheduled Full Committee meeting. Due Dates for other IACUC applications and forms Colony Applications: These applications may be submitted any time and will be reviewed using the Designated Member Review system within 2 weeks of receipt of the application. However, all applications are subject to potential review in Full Committee. Review Exemption Policy A. Non-intrusive field research (observation only, no significant manipulation of the animal or its environment) USDA Pain Categories
Significant Change to Approved Animal Care and Use Policy (Amending approved applications) Examples of changes considered to be significant include, but are not limited to, changes: 1. in the objectives of a study; Collaborations with Other Institutions (Duplicative Review) Field studies Use of standard operating procedures (SOPs) in lieu of repeating descriptions of identical procedures in multiple protocols Review System and Process for NMU IACUC Animal Use Applications and Colony Applications: 1. Application Submission 2. Administrative Review 3. Designated Member Review 4. Full Committee Review 5. Approval: Conflict of Interest Conflict of Obligation Amending approved protocols Post-Approval Monitoring Holding Protocols Procedure: Care of the animals covered under the Animal Holding Protocol will be delegated to the Chair of the Institutional Animal Care and Use Committee or, at the discretion of this committee, the head of the department where the animals are housed. No experimental procedures can be conducted on animals covered by the Animal Holding Protocol. Feeding, watering, sanitation, and all other basic care animals functions will be performed as expected for the species. All appropriate veterinary animal care will be provided, as needed. The Animal Holding Protocol is temporary. For renewal, new or amended applications, the application must be submitted within one week of the IACUC transferring these previously covered animals to the Animal Holding Protocol. If a new or amended protocol has not been submitted, then the animals will be euthanized or adopted out. The Holding Protocol may remain in effect for four weeks (in order to allow for review) upon which time it is expected that the new or amended protocol will go into effect or the animals will be euthanized or adopted out. Should it be necessary under extraordinary circumstances, the Chair of the IACUC may renew a Holding Protocol once for an additional four weeks. Thus, animals should remain on a Holding Protocol for no more than eight weeks under extraordinary circumstances. During the period of a Holding Protocol, the financial responsibility for the care of the affected animals remains with the originating investigator. This financial responsibility may include transportation, feed costs, and labor; rates are at the discretion of the IO in consultation with the IACUC. During this period, no costs may be applied to existing grants/contracts associated with the original research project for which the animals were brought on campus. Records of approved IACUC applications ANIMAL ACQUISITION AND DISPOSITION Animals are to be acquired by lawful means. Animals that are purchased are to come from animal vendors with a tradition of producing consistently healthy animals in compliance with applicable laws, statutes and regulations, and institutional needs. Collection of animals in the wild must be in accord with appropriate permits. Breeding Colonies Disposition Animals used for research, research training, experimentation, teaching or in breeding colonies may be disposed by 5 methods. Adoption Policy The person adopting NMU laboratory animals must agree in writing that the health and temperament of the animal is not guaranteed (i.e., the animal is adopted “as is”), that all reasonable attempts to appropriately care for the animal are made, that the animal is to be only kept as a pet and not to be released from the person’s care, and that neither NMU nor any employee or student of NMU will be held liable for the actions or circumstances that arise from the adopted animal. No more than two animals will be adopted to an individual per year. An adoption form is located in the appendix of the NMU IACUC Policy. INSPECTIONS OF ANIMAL HOUSING AND USE SITES The IACUC will prepare reports of evaluations and submit the report to the Dean of Graduate Studies and Research (Institutional Official). (NOTE: the reports shall be updated at least once every six months upon completion of the required semiannual evaluations and shall be maintained by the institution and made available to OLAW upon request.) The reports will be submitted by the Chair of the IACUC and contain description of the nature and extent of the institution’s adherence to the Guide and this Policy and will identify specifically any departures from the provision of the Guide and this Policy, and must state reasons for each departure. The reports must distinguish significant deficiencies from minor deficiencies. A significant deficiency is one which, consistent with this Policy, and, in the judgment of the IACUC is or may be a threat to the health or safety of the animals. If program or facility deficiencies are noted, the reports must contain a reasonable and specific plan and schedule for correcting each deficiency. The IACUC shall report in writing the results of visits to the animal housing and use sites. These reports shall be maintained for 3 years. For Inspectors * Entry and exit restrictions in areas to be inspected Conducting the inspection Reporting inspection
findings The report should list the deficiencies found and categorize these deficiencies as Significant or Minor. Significant deficiencies are those that jeopardize the health and well being of animals in the facility and must, therefore, be resolved quickly. Inspectors are encouraged to communicate with principle investigators to insure the accuracy of this report as well as to develop a reasonable time line for the deficiencies to be resolved. If the deadline set for resolving these deficiencies is not met, then, according to Animal Welfare Act Regulations, the Principal Investigator will have 15 days to resolve the matter before a report must be filed to the USDA or OLAW. Further, the IACUC will suspend all animal research activities associated with the deficiency. For
Principal Investigators RECORD KEEPING REQUIREMENTS
The NMU IACUC investigates reports of the conduct of animal-related research and/or teaching/training activities that occur without IACUC review and approval, or failure to comply with IACUC approved protocols, disregard for institutional policies and procedures, violation of laws, regulations, or policies governing animal use, or participation in activities that may have misused or abused animals. Policy on Persons Reporting Violations Definitions For the purposes of this policy, Deficiencies are categorized as Significant or Minor: 1. Significant: one that is or may be a threat to the health or safety of the animals (9CFR2.31(c)(3) and PHS IV.B.3). Further, animals being used for research, teaching or other activities on campus that are not covered by an approved IACUC (including expired protocols) shall be considered under significant deficiency. 2. Minor: any deficiency not considered significant. For the purposes of this policy, Concerns include 1. Concerns or reports received from members of the public regarding the care and use of animals at any of the NMU facilities (including field sites), or Reporting The University's veterinarian, or his/her designee, unilaterally may decide to euthanize an animal in extreme distress or pain that cannot be alleviated, if euthanasia is determined to be in the best interest of the animal. Similarly, the University's veterinarian, or his/her designee, unilaterally may ask an investigator to cease procedures in process when the veterinarian determines the animal to be in extreme distress or pain, if cessation of work in progress is determined to be in the best interest of the animal. All reasonable attempts to receive advice from the above individuals and the principal investigator (PI) should be exhausted before such decisions are made. A written record of such action will be submitted to the IACUC on the next working day. Significant
Deficiencies Minor Deficiencies Concerns and Complaints Concerns should first be addressed to the implicated individual(s) or unit. If the concern is not adequately addressed, or if there is fear of retribution, the concern should be taken immediately to the next level by contacting any member of the IACUC or the IO. The contacted IACUC member must report the concern to the IACUC chair or designee, and the merits of filing a formal complaint will be determined. Either a phone call, verbal report, written contact or completion of the Anonymous Reporting of Animal Research Concerns online form can initiate the report of a concern, but a formal signed complaint will be necessary prior to the IACUC's review. The IACUC Chair, or IACUC member will assist the complainant in completing the written description and will submit the Formal Complaint to the IACUC chair. The Formal Complaint may be initiated by an IACUC member. While hearsay complaints cannot be formally filed, individuals who have serious concerns based on hearsay evidence can contact any member of the IACUC or the Institutional Officer. An IACUC member will follow up on concerns by means other than the formal complaint process (such as review of protocols, discussions with other employees, or unannounced laboratory inspections). Documentation of concerns may be collected at this time. This process may lead to the filing of a Formal Complaint. Complainants in a Formal Complaint must be the actual individual(s) who have witnessed the violation. Significant deficiencies that are identified at any stage of this process will be addressed as described above. Initial Review of a Formal Complaint Investigation
of a Formal Complaint ** Citation of the section of the federal regulations which allow for investigations of concerns related to animal care and use. ** Description of the complaint and the IACUC’s initial report. ** An invitation to meet with the IACUC Chair, to personally discuss the allegation. The IACUC may use
a variety of methods to obtain information to assist in the investigation. b. Submission of documentation from the PIND, co-workers or employees, or from the animal facility where animals were housed. Such documentation could include: research records relating to animal experimentation, surgical records, animal health records, purchase orders, standard operating procedures, diagnostic laboratory reports, quality assurance reports, or others which will provide information which will assist in the investigation. c. Documentation supporting the allegations provided by the Complainant. The PIND will be invited to provide a written response to the Complaint and any additional documentation provided by the Complainant. d. Review of Animal Care and Use Protocols, IACUC inspection reports, Reports of Programmatic Reviews, or USDA inspection reports, or any other pertinent IACUC record. e. Letters or documentation solicited from other University employees who can provide insight into the investigation. f. Letters of outside evaluation of protocols, programs, or documentation related to the complaint performed by external reviewers chosen by the Committee. Such reviews would be done confidentially, with signed confidentiality statements by reviewers. The PIND may be asked to assist the IACUC in selection of reviewers. g. Invited site visits by external reviewer(s) to critique facilities or programs. h. IACUC interviews with the PIND, Complainant or other individuals who can provideinformation for the investigation. Once the IACUC has completed its fact gathering period, the IACUC will reconvene to review all of the information. A quorum of the Committee must be present at the meeting. Several individual members of the IACUC may be selected to review and summarize information which will be presented to the IACUC. Individual members will have access to all documentation, should they wish to review the entire package. The Committee will review the package and fully discuss all issues. Once discussion is complete, the Committee will form recommendations for action. Recommendations will be individually voted on and all actions must pass by a majority vote. Such actions could include, but are not limited to: ** Find that the Complaint was unwarranted or unsubstantiated. Should charges be brought that are false and in a malicious manner by the Complainant to purposely harm the University or any of its departments, divisions, or units, the IACUC, or any individual, then such will be handled according to pertinent policies of Northern Michigan University which are applicable to the given case. ** Requiring an amendment to the IACUC approved protocol. ** Requiring a change in procedures previously approved in an IACUC protocol or requiring a change in procedures or program of the animal facility in question. ** Requiring a re-submission of a currently approved IACUC protocol ** Conducting unannounced laboratory inspections or unannounced facility visits to observe conditions, procedures, and/or review programs. The end result of the inspection(s) may include any of the actions outlined in this section. ** Suspension of the research activity (Protocol). ** Sanction of the Animal Care Program in question. With the Investigation complete and actions initially recommended, the IACUC will invite the PIND to meet with the IACUC to review the findings. This meeting will provide an opportunity for the PIND and IACUC to resolve issues and work together to find solutions to the issues raised in the investigation. Harsh actions such a suspension or sanction can hopefully be avoided by this process and result in the mutual agreement and satisfaction of the IACUC and the PIND. After the PIND has met with the IACUC, the IACUC will formulate its final actions and vote on these individually. All actions must pass by a majority of quorum vote and minority opinions be recorded. The Committee shall complete the investigation by the following documentation and notifications: a. The Institutional Official shall receive a summary document of the findings of the Committee and the final actions to be taken. b. If suspension is imposed on a PHS-supported activity, the Institutional Official shall file a full report with OLAW. A full report, for suspensions involving covered species, must also be filed with the USDA. c. If sanction of the animal care program is to occur, the letter will be directed to the administrator of the program and will be written jointly with the Institutional Official. d. The Complainant will receive a summary of the actions taken, but confidential information concerning protocols will not be included. e. The PIND will be informed, in writing, of the final conclusions/actions of the Committee and of any response that is required from the PIND. f. If the Complaint was found to be unwarranted or unsubstantiated, a strong letter of support will be provided to the PIND from the Committee for the research, animal care facility, or other program, as appropriate. g. The Committee will complete a final report and close the file, keeping all documentation for the complaint, review, investigation, and all other information. h. The IACUC Chair will provide letters of appreciation to all individuals who assisted in the completion of the investigation. Confidentiality of the Complainant Relevant Authority Citations Related to inspections and the semi-annual review of programs: 9CFR2.31(c)(3): "If [in the semi-annual review of programs] program or facility deficiencies are noted, the reports must contain a reasonable and specific plan and schedule with dates for correcting each deficiency. Any failure to adhere to the plan and schedule that results in a significant deficiency remaining uncorrected shall be reported in writing within 15 business days by the IACUC, through the Institutional Official, to APHIS and any Federal agency funding that activity; PHS: IV.B.3: Report of the semi-annual review of programs "must identify specifically any departures from the provisions of the Guide and this Policy, and must state the reasons for each departure. The reports must distinguish significant deficiencies from minor deficiencies. If program or facility deficiencies are noted, the reports must contain a reasonable and specific plan and schedule for correcting each deficiency." Suspension of work in progress: 9CFR2.31(d)(6) and PHS: IV.C.6: "The IACUC may suspend an activity only after review of the matter at a convened meeting of a quorum of the IACUC and with the suspension vote of a majority of the quorum present." 9CFR2.31(d)(7) and PHS: IV.C.7: "If the IACUC suspends an activity involving animals, the Institutional Official in consultation with the IACUC shall review the reasons for suspension, take appropriate corrective action, and report that action with a full explanation to OLAW [APHIS] and any Federal agency funding that activity". Review of concerns about the use of animals: 9CFR2.31(c)(4): "Review, and, if warranted, investigate concerns involving the care and use of animals at the research facility resulting from public complaints received and from reports of noncompliance received from laboratory or research facility personnel or employees;" PHS IV.B.4: With respect to PHS-conducted or supported activities, the IACUC shall "review concerns involving the care and use of animals at the institution" and "be authorized to suspend an activity involving animals" as set forth in IV.C.6. Reporting requirements in addition to the above: PHS: IV.F.3: The IACUC, through the Institutional Official, shall promptly provide OPRR with a full explanation of the circumstances and actions taken with respect to: Authority: 9CFR2.31(d)(6): "The IACUC may suspend an activity that it previously approved if it determines that the activity is not being conducted in accordance with the description of that activity provided by the principal investigator and approved by the Committee." PHS IV.C.6: "The IACUC may suspend an activity that it previously approved if it determines that the activity is not being conducted in accordance with applicable provisions of the Animal Welfare Act, the Guide, the institution's Assurance, or IV.C.1.a.-g. of this Policy." 9CFR2.31(c)(8): The IACUC shall "be authorized to suspend an activity involving animals in accordance with the specifications set forth in" 9CFR2.31(d)(6) above. 9CFR2.31(c)(3): With respect to activities involving animals, the IACUC shall conduct evaluations and prepare reports of such evaluations. "The reports must contain a description of the nature and extent of the research facility's adherence to this subchapter, must identify specifically any departures from the provisions of title 9, chapter I, subchapter A--Animal Welfare, and must state the reasons for each departure. The reports must distinguish significant deficiencies from minor deficiencies. REFERENCES FOR THE NMU IACUC POLICY Animal Welfare Act Regulations (USDA) APPENDIX TYPE OF EMERGENCY OR DISASTER - CATEGORIES AND LEVELS
Emergency Procedures Template to be placed in Laboratory Laboratory / Facility Supervisor: ______________________ Report suspicious activities or major environmental concerns (e.g., major temperature change), to Public Safety at 227-2151 (on campus, dial 2151) For emergencies, call 911. For reporting minor concerns after hours, contact the following individuals in order: 1. 2. 3. Concerns regarding the treatment of animals: Contact the facility or laboratory supervisor. You may also contact Dr. Brian Cherry, IACUC Officer, at 227-2300 (on campus, dial 2300) or any member of the IACUC. An anonymous reporting form is available online at: http://www.nmu.edu/grantsandresearch/node/96 Institutional Veterinarian: Dr. Laura Klar, DVM List of abbreviations APHIS, Animal and Plant Health Inspection Service; AWAR, Animal Welfare Act Regulations; the Guide, Guide for the Care and Use of Laboratory Animals; IACUC, Institutional Animal Care and Use Committee; IO, Institutional Officer; NIH, National Institutes of Health; NMU, Northern Michigan University; OLAW, Office of Laboratory Animal Welfare; PHS, Public Health Service; PI, Principal Investigator; PIND, Principal Investigator, Animal Facility Manager or other pertinent individual; PPE, Personal Protection Equipment; SOP, Standard Operating Procedure; USDA, United States Department of Agriculture Which of the following is considered a minor change that would not require a formal IAC You see review and approval?Which of the following is considered a minor change that would not require formal IACUC review and approval? A change in personnel.
Which of the following significant changes to a protocol could be administratively approved in principle by WVC?Which of the following significant changes to a protocol could be administratively approved (in principle) by VVC? With an existing policy approved by the IACUC, a change in analgesic agent could be approved by VVC.
Which of the following are the responsibility of the IACUC?Responsibilities. The IACUC is responsible for oversight of the animal care and use program and its components as described in the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (Policy) and the Guide for the Care and Use of Laboratory Animals (Guide ).
Is IACUC required?Institutional Animal Care and Use Committee (IACUC) approval is required before conducting research and teaching activities involving vertebrate animals if ANY of the following categories apply: Animals involved are owned or leased by TAMU-CC.
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