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What Is Spironolactone and How Does It Work?Spironolactone is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems.
What Are Dosages of Spironolactone?Dosages of Spironolactone: Adult and Pediatric Dosage Forms and Strengths Tablet
Dosage Considerations – Should be Given as Follows: Primary Hyperaldosteronism As a diagnostic agent
Short-term perioperative treatment for adrenalectomy
Geriatric, Initial: 400 mg/day orally, THEN 100-300 mg/day Edematous Conditions
Edema, Pediatric (Off-label)
Essential Hypertension
Congestive Heart Failure Adult and Geriatric
Hypokalemia
Diuresis, Geriatric
Hirsutism (Off-label) Women with hirsutism
Acne (Off-label) Females with hormonal acne
Hyperaldosteronism (Orphan), Pediatric Orphan designation for primary hyperaldosteronism Sponsor
Dosing Modifications Renal impairment
Dosing considerations Geriatric
Overdose Management
QUESTIONIn the U.S., 1 in every 4 deaths is caused by heart disease. See AnswerWhat Are Side Effects Associated with Using Spironolactone?Common side effects of spironolactone include:
This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What Other Drugs Interact with Spironolactone?If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider, or pharmacist first. Severe interactions of spironolactone include:
Serious interactions of spironolactone include:
Spironolactone has moderate interactions with at least 189 different drugs. Spironolactone has mild interactions with at least 41 different drugs. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns. What Are Warnings and Precautions for Spironolactone?WarningsSpironolactone is tumorigenic in chronic toxicity studies in rats; use only for specified indications. This medication contains spironolactone. Do not take Aldactone if you are allergic to spironolactone or any ingredients contained in this drug. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately. Contraindications
Effects of Drug Abuse
Short-Term Effects
Long-Term Effects
Cautions
Pregnancy and Lactation
SLIDESHOWHeart Disease: Symptoms, Signs, and Causes See SlideshowFromWhat drugs are used to treat hyperaldosteronism?The treatment of hyperaldosteronism depends on the cause. If the cause is hyperplasia in both adrenal glands, your doctor may prescribe a drug that blocks the effects of aldosterone. These drugs include spironolactone (Aldactone®), eplerenone (Inspra®), or amiloride (Midamor®).
What is the most common cause of hyperaldosteronism?Hyperaldosteronism occurs when the adrenal glands release too much aldosterone. Primary hyperaldosteronism is due to a problem of the adrenal glands themselves. Most cases are caused by a noncancerous (benign) tumor of the adrenal gland.
Which intervention with the nurse take for a patient with hyperaldosteronism?Aldosterone-blocking drugs – medications that can stop the production of aldosterone can be used to treat hyperaldosteronism. These are also the treatment of choice in individuals who are not fit to have surgical removal of the adrenal gland with the tumor.
Which finding is consistent with the diagnosis of hyperaldosteronism?Primary hyperaldosteronism is diagnosed by measuring the blood levels of aldosterone and renin (a hormone made by the kidney). To best measure these hormones, blood samples should be drawn in the morning. In primary hyperaldosteronism, the aldosterone level will be high while renin will be low or undetectable.
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