Which oral medication should the nurse question before administering to the client with pud?

Peptic ulcer is an ulceration in the mucosal wall of the lower esophagus, stomach, pylorus, or duodenum. The ulcer may be referred to as duodenal, gastric, or esophageal, depending on its location. The most common symptom of both gastric and duodenal ulcers is epigastric pain. It is characterized by a burning sensation and usually occurs shortly after meals with gastric ulcer and 2-3 hours afterward with duodenal ulcer.

Predisposing factors of peptic ulcer includes infection with the gram-negative bacteria Helicobacter pylori which may be acquired through the ingestion of food and water, excessive HCL secretion in the stomach, chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) which weakens the lining of the GI tract by reducing the protective function of the mucosal layer, increased stress associated with illness and surgery, alcohol ingestion and excessive cigarette smoking.

The nursing goals of a client with a peptic ulcer disease include reducing or eliminating contributing factors, promoting comfort measures, promoting optimal nutrition, decreasing anxiety with increased knowledge of disease, management, and prevention of ulcer recurrence and preventing complications

Here are five (5) nursing care plans (NCP) and nursing diagnosis for patients with peptic ulcer disease:


  1. Acute Pain
  2. Imbalanced Nutrition: Less Than Body Requirements
  3. Anxiety
  4. Deficient Knowledge
  5. Risk For Deficient Fluid Volume

1. Acute Pain

Acute Pain

Nursing Diagnosis

  • Acute Pain

May be related to

  • Abdominal distention
  • Abdominal muscle spasm
  • Recent nonsteroidal anti-inflammatory drug (NSAID) or acetylsalicylic acid (ASA) use

Possibly evidenced by

  • Early satiety
  • Nausea and vomiting
  • Pain relieved by food or antacid
  • Weight loss

Desired Outcomes

  • Client will report satisfactory pain control at a level less than 2 to 4 on a scale of 0 to 10.
  • Client uses pharmacological and nonpharmacological pain relief measures.
  • Client will exhibit increased comfort such as baseline levels for HR, BP, and respirations and relaxed muscle tone for body posture.
Nursing InterventionsRationale
Assess the client’s pain, including the location, characteristics, precipitating factors, onset, duration, frequency, quality, intensity, and severity. Clients with gastric ulcer typically demonstrate pain 1 to 2 hours after eating. The client with duodenal ulcers demonstrate pain 2 to 4 hours after eating or in the middle of the night. With both gastric and duodenal ulcers, the pain is located in the upper abdomen and is intermittent. Client may report relief after eating or taking an antacid.
Encourage the use of nonpharmacological pain relief measures:
  • Acupressure
  • Biofeedback
  • Distraction
  • Guided imagery
  • Massage
  • Music therapy
Nonpharmacological relaxation techniques will decrease the production of gastric acid, which in turn will reduce pain.
Instruct the client to avoid NSAIDs such as aspirin. These medications may cause irritation of the gastric mucosa.
Instruct the client that meals should be eaten ar regularly paced intervals in a relaxed setting. An irregular schedule of meals may interfere with the regular administration of medications.
Encourage the importance of smoking cessation. Smoking decreases the secretion of bicarbonate from the pancreas into the duodenum, resulting in increased acidity of the duodenum.
Administer the prescribed drug therapy:
  • Antacids
  • Antibiotics such as amoxicillin, clarithromycin, metronidazole, tetracycline
  • Histamine receptor antagonists
  • Prostaglandin analogues
  • Proton pump inhibitor
  • Sucralfate
Antacids buffer gastric acid and prevent the formation of peptin. This mechanism of action promotes of healing of the ulcer. Antibiotics treat the Helicobacter pylori infection and promote healing of the ulcer. As the ulcer heals, the client experience less pain. H2 receptor antagonists block the secretion of gastric acid. Prostaglandin analogue reduces acid secretion and enhance the integrity of the gastric mucosa to resist injury. Proton pump inhibitors block the production and secretion of gastric acid and thereby reduce gastric pain. Sucralfate forms a barrier at the base of the ulcer crater to protect the healing ulcer from gastric acid.

1. Acute Pain

Recommended nursing diagnosis and nursing care plan books and resources.

Disclosure: Included below are affiliate links from Amazon at no additional cost from you. We may earn a small commission from your purchase. For more information, check out our privacy policy.

  • Nursing Care Plans: Nursing Diagnosis and Intervention (10th Edition)
    An awesome book to help you create and customize effective nursing care plans. We highly recommend this book for its completeness and ease of use.
  • Nurse’s Pocket Guide: Diagnoses, Prioritized Interventions and Rationales
    A quick-reference tool to easily select the appropriate nursing diagnosis to plan your patient’s care effectively.
  • NANDA International Nursing Diagnoses: Definitions & Classification, 2021-2023 (12th Edition)
    The official and definitive guide to nursing diagnoses as reviewed and approved by the NANDA-I. This book focuses on the nursing diagnostic labels, their defining characteristics, and risk factors – this does not include nursing interventions and rationales.
  • Nursing Diagnosis Handbook, 12th Edition Revised Reprint with 2021-2023 NANDA-I® Updates
    Another great nursing care plan resource that is updated to include the recent NANDA-I updates.
  • Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5(TM))
    Useful for creating nursing care plans related to mental health and psychiatric nursing.
  • Ulrich & Canale’s Nursing Care Planning Guides, 8th Edition
    Claims to have the most in-depth care plans of any nursing care planning book. Includes 31 detailed nursing diagnosis care plans and 63 disease/disorder care plans.
  • Maternal Newborn Nursing Care Plans (3rd Edition)
    If you’re looking for specific care plans related to maternal and newborn nursing care, this book is for you.
  • Nursing Diagnosis Manual: Planning, Individualizing, and Documenting Client Care (7th Edition)
    An easy-to-use nursing care plan book that is updated with the latest diagnosis from NANDA-I 2021-2023.
  • All-in-One Nursing Care Planning Resource: Medical-Surgical, Pediatric, Maternity, and Psychiatric-Mental Health (5th Edition)
    Definitely an all-in-one resources for nursing care planning. It has over 100 care plans for different nursing topics.

See also

Other recommended site resources for this nursing care plan:

  • Nursing Care Plans (NCP): Ultimate Guide and Database MUST READ!
    Over 150+ nursing care plans for different diseases and conditions. Includes our easy-to-follow guide on how to create nursing care plans from scratch.
  • Nursing Diagnosis Guide and List: All You Need to Know to Master Diagnosing
    Our comprehensive guide on how to create and write diagnostic labels. Includes detailed nursing care plan guides for common nursing diagnostic labels.

More nursing care plans related to gastrointestinal disorders:

  • Appendectomy | 4 Care Plans
  • Cholecystectomy | 12 Care Plans
  • Cholecystitis and Cholelithiasis | 4 Care Plans
  • Gastroenteritis | 4 Care Plans
  • Hemorrhoids | 3 Care Plans
  • Hepatitis | 7 Care Plans
  • Ileostomy & Colostomy | 10 Care Plans
  • Inflammatory Bowel Disease | 7 Care Plans
  • Intussusception | 3 Care Plans
  • Liver Cirrhosis | 8 Care Plans
  • Pancreatitis | 8+ Care Plans
  • Peritonitis | 6 Care Plans
  • Peptic Ulcer Disease | 5 Care Plans
  • Subtotal Gastrectomy | 2 Care Plans

Paul Martin is a registered nurse with a bachelor of science in nursing since 2007. Having worked as a medical-surgical nurse for five years, he handled different kinds of patients and learned how to provide individualized care to them. Now, his experiences working in the hospital is carried over to his writings to help aspiring students achieve their goals. He is currently working as a nursing instructor and have a particular interest in nursing management, emergency care, critical care, infection control, and public health. As a writer at Nurseslabs, his goal is to impart his clinical knowledge and skills to students and nurses helping them become the best version of themselves and ultimately make an impact in uplifting the nursing profession.

What medications should be avoided with peptic ulcer disease?

These drugs include the prescription and over-the-counter medications omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), esomeprazole (Nexium) and pantoprazole (Protonix). Long-term use of proton pump inhibitors, particularly at high doses, may increase your risk of hip, wrist and spine fracture.

What is the drug of choice for PUD?

Proton pump inhibitors (PPIs) are drugs that block the three major pathways for acid production. PPIs suppress acid production much more effectively than H2 blockers. PPIs are the gold standard in medication therapy of peptic ulcer disease. Medications to protect and strengthen the mucous lining of the stomach.

What is the first line treatment for PUD?

Vonoprazan (VPZ) with antibiotics is recommended as the first-line treatment for H. pylori eradication, and PPIs or VPZ with antibiotics is recommended as a second-line therapy.

Why are NSAIDs contraindicated in PUD?

Ulcers and NSAIDs Peptic ulcer disease is a well-recognised complication of NSAID use. Inhibition of COX-1 in the gastrointestinal tract leads to a reduction of prostaglandin secretion and its cytoprotective effects in gastric mucosa. This therefore increases the susceptibility to mucosal injury.