Show DRUG INTERACTIONSAcetaminophen; Aspirin, ASA; Caffeine: (Moderate) When coadministered with aspirin, ASA (doses between 500 mg and 1000 mg), the maximum plasma concentration (Cmax) and exposure (AUC) of a single nitroglycerin dose is increased by 67% and 73%, respectively. Additionally, limited data suggest that patients receiving aspirin, ASA in high doses can exhibit an exaggerated response to sublingual nitroglycerin. Although hypotension and tachycardia were more significant during concomitant therapy, no special precautions appear necessary. The pharmacologic effects of 0.4% nitroglycerin rectal ointment may also be enhanced when administered concomitantly with aspirin, ASA; therefore, close clinical monitoring is advised. What is a contraindication to administering nitroglycerin?Nitroglycerin is contraindicated in patients that have reported allergic symptoms to the medication. [18] Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.
Which of the following are CONTRAINDICATIONS for nitroglycerine quizlet?What are the CONTRAINDICATIONS for administering Nitroglycerin? Hypotension, hypovolemia, intracranial bleeding or head injury, pericardial tamponade, severe bradycardia or tachycardia, RV infarction, previous administration in the last 24 hours: tadalafil (Cialis) (48 hours), vardenafil (Levitra), sildenafil (Viagra).
What is a contradiction to nitrate administration?Several contraindications exist for the use of nitrate. [3] They are the following: Allergy to nitrates. Concomitant use of phosphodiesterase (PDE) inhibitors such as tadalafil and sildenafil. Right ventricular infarction.
Is hypotension a contraindication for nitroglycerin?"Nitrates should not be given to patients with hypotension, marked bradycardia or tachycardia, RV infarction, or 5'phosphodiesterase inhibitor use within the previous 24 to 48 hours."
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