The blood circulatory system (cardiovascular system) delivers nutrients and oxygen to all cells in the body. It consists of the heart and the blood vessels running through the entire body. The arteries carry blood away from the heart; the veins carry it back to the heart. The system of blood vessels resembles a tree: The “trunk” – the main artery (aorta) – branches into large arteries, which lead to smaller and smaller vessels. The smallest arteries end in a network of tiny vessels known as the capillary network. Show
There isn't only one blood circulatory system in the human body, but two, which are connected: The systemic circulation provides organs, tissues and cells with blood so that they get oxygen and other vital substances. The pulmonary circulation is where the fresh oxygen we breathe in enters the blood. At the same time, carbon dioxide is released from the blood. Blood circulation starts when the heart relaxes between two heartbeats: The blood flows from both atria (the upper two chambers of the heart) into the ventricles (the lower two chambers), which then expand. The following phase is called the ejection period, which is when both ventricles pump the blood into the large arteries. In the systemic circulation, the left ventricle pumps oxygen-rich blood into the main artery (aorta). The blood travels from the main artery to larger and smaller arteries and into the capillary network. There the blood drops off oxygen, nutrients and other important substances and picks up carbon dioxide and waste products. The blood, which is now low in oxygen, is collected in veins and travels to the right atrium and into the right ventricle. This is where pulmonary circulation begins: The right ventricle pumps low-oxygen blood into the pulmonary artery, which branches off into smaller and smaller arteries and capillaries. The capillaries form a fine network around the pulmonary vesicles (grape-like air sacs at the end of the airways). This is where carbon dioxide is released from the blood into the air inside the pulmonary vesicles, and fresh oxygen enters the bloodstream. When we breathe out, carbon dioxide leaves our body. Oxygen-rich blood travels through the pulmonary veins and the left atrium into the left ventricle. The next heartbeat starts a new cycle of systemic circulation. Sources
Medical Terminology for Cancer© Copyright 1996-2013 ContentsFunctions of the cardiovascular systemBlood Blood vessels The heart The spleen Roots, suffixes, and prefixes Cancer Focus Related Abbreviations and Acronyms Further Resources Functions of the cardiovascular systemBlood circulates through a network of vessels throughout the body to provide individual cells with oxygen and nutrients and helps dispose of metabolic wastes. The heart pumps the blood around the blood vessels. Functions of blood and circulation:
BloodBlood is made up of about 45% solids (cells) and 55% fluids (plasma). The plasma is largely water, containing proteins, nutrients, hormones, antibodies, and dissolved waste products. General types of blood cells: (each has many different sub-types) ERYTHROCYTES(red cells) are small red disk shaped cells. They contain HAEMOGLOBIN, which combines with oxygen in the lungs and is then transported to the body's cells. The haemoglobin then returns carbon dioxide waste to the lungs. Erythrocytes are formed in the bone marrow in the knobby ends of bones.LEUKOCYTES(white cells) help the body fight bacteria and infection. When a tissue is damaged or has an infection the number of leukocytes increases. Leukocytes are formed in the small ends of bones. Leukocytes can be classed as granular or non granular. There are three types of granular leukocytes (eosinophils, neutrophils, and basophils), and three types of non-granular (monocytes, T-cell lymphocytes, and B-cell lymphocytes). See also the lymphatic system.THROMBOCYTES(platelets) aid the formation of blood CLOTS by releasing various protein substances. When the body is injured thrombocytes disintegrate and cause a chemical reaction with the proteins found in plasma, which eventually create a thread like substance called FIBRIN. The fibrin then "catches" other blood cells which form the clot, preventing further loss of blood and forms the basis of healing.Blood vessels Image source: http://commons.wikimedia.org/wiki/File:Illu_capillary.jpg The heartThe heart is a hollow muscular organ which beats over 100,000 times a day to pump blood around the body's 60,000 miles of blood vessels. The right side of the heart receives blood and sends it to the lungs to be oxygenated, while the left side receives oxygenated blood from the lungs and sends it out to the tissues of the body. The Heart has three layers; the ENDOCARDIUM (inner layer), the EPICARDIUM (middle layer), and MYOCARDIUM (outer layer). The heart is protected by the PERICARDIUM which is the protective membrane surrounding it. The heart has FOUR CHAMBERS, in the lower heart the right and left Ventricles, and in the upper heart the right and left Atria. In a normal heart beat the atria contract while the ventricles relax, then the ventricles contract while the atria relax. There are VALVES through which blood passes between ventricle and atrium, these close in such a way that blood does not backwash during the pauses between ventricular contractions. The right and left ventricles are divided by a thick wall (the VENTRICULAR SEPTUM), babies born with "hole in the heart" have a small gap here, which is a problem since oxygenated and deoxygenated can blood mix. The walls of the left ventricle are thicker as it has to pump blood to all the tissues, compared to the right ventricle which only pumps blood as far as the lungs. The spleenThis is a large flat oval organ located below the diaphragm, it's main function is to STORE BLOOD. The size of the spleen can vary, for example it may enlarge when the body is fighting infection also it's size tends to decrease with age. It is a non-vital organ and it is possible to survive after removal of the spleen. Perinicious anaemia is a Vitamin B12 deficiency resulting in a reduction in number of erythrocytes. Aplastic anemia is a failure of the bone marrow to produce the enough red blood cells. Septicaemia - bacterial toxins in blood. Roots, suffixes, and prefixesMost medical terms are comprised of a root word plus a suffix (word ending) and/or a prefix (beginning of the word). Here are some examples related to the Integumentary System. For more details see Chapter 4: Understanding the Components of Medical Terminology
Cancer FocusOverview of Haematological MalignanciesThe most common haematological malignancy is leukaemia - cancer of the white blood cells. There are many types of leukaemia; Acute types progress rapidly, while Chronic types develop more slowly. Leukaemia is often accompanied by anaemia because the red oxygen carrying cells in the blood are crowded out by the cancerous white cells. There are a number of malignancies and disorders affecting other types of blood cells. Internet Resources for LeukaemiaAcute Lymphoblastic Leukaemia (ALL)Acute lymphoblastic leukaemia (also known as acute lymphocytic leukaemia or ALL) is a disease where too many immature lymphocytes (a type of white blood cell) are found in the blood and bone marrow. Symptoms can include persistent fever, weakness or tiredness, achiness in the bones or joints, or swollen lymph nodes. Adult ALL and its treatment is usually different to childhood ALL. Almost a third of adult patients have a specific chromosome translocation; "Philadelphia Positive" ALL. Internet Resources for Acute Lymphoblastic LeukaemiaAcute Myeloid Leukaemia (AML)Acute myeloid leukemia (AML) is a disease in which too many immature granulocytes (a type of white blood cell) are found in the blood and bone marrow. There are a number of subtypes of AML including acute myeloblastic leukemia, acute promyelocytic leukemia, acute monocytic leukemia, acute myelomonocytic leukemia, erythroleukemia, and acute megakaryoblastic leukemia. Internet Resources for Acute Myeloid LeukaemiaOther Types of Leukaemia Chronic Lymphocytic LeukaemiaChronic Myelogenous Leukaemia Hairy Cell Leukaemia Internet Resources for LeukaemiaChildhood LeukaemiaChildhood leukaemias tend to have different characteristics and treatments compared to adult leukaemias. There is a "childhood peak" of Acute Lymphoblastic Leukaemia, there is a lower proportion of Acute Myeloid Leukaemias compared to adult patients. Clinical prognostic factors include age, White Blood Cell count (WBC) at presentation, and Central Nervous System (CNS) involvement. Infants less than 1 year and adolescents over 10 years of age, WBC greater than 50,000, or CNS involvement are associated with a less favourable prognosis. Internet Resources for Childhood LeukaemiaOther Haematological Malignancies - LymphomasThese are covered in the chapter on the Lymphatic System - Myelodysplastic SyndromesMyelodysplastic syndromes, sometimes called "pre-leukaemia" are a group of diseases in which the bone marrow does not produce enough normal blood cells. Common symptoms are anaemia, bleeding, easy bruisability, and fatigue. These Myelodysplastic syndromes can occur in all age groups but are more common in people aged over 60. Myelodysplastic syndromes may develop spontaneously or be secondary to treatment with chemotherapy / radiotherapy. There is an association with Myelodysplastic syndromes and acute myeloid leukaemia. - Myeloproliferative DisordersMyeloproliferative disorders are diseases in which too many blood cells are made by the bone marrow, there are 4 main types of myeloproliferative disorders: chronic myelogenous leukaemia, polycythemia vera, agnogenic myeloid metaplasia, and essential thrombocythemia. Chronic myelogenous leukaemia is where an excess of granulocytes (immature white blood cells) are found in the blood and bone marrow. Polycythemia vera is where red blood cells become too numerous often resulting in a swelling of the spleen. Agnogenic myeloid metaplasia is a condition in which certain blood cells do not mature properly, this may result in a swelling of the spleen and anaemia. Essential thrombocythemia is a disease in which the body produces excessive numbers of platelets (cells in the blood that make it clot) which impedes the normal circulation of blood. - Aplastic AnaemiaAnaplastic Anemia is not a cancer. AA is a rare disease in which the bone marrow is unable to produce adequate blood cells; leading to pancytopenia (deficiency of all types of blood cells). AA may occur at any age, but there is a peak in adolescence / early adulthood, and again in old age. Slightly more males than females are diagnosed with AA, also the disease is more common in the Far East. Patients successfully treated for aplastic anemia have a higher risk of developing other diseases later in life, including cancer. - Fanconi AnaemiaFanconi Anaemia is not a cancer, it is a rare disorder found in children that involves the blood and bone marrow. The symptoms include severe aplastic anemia, hypoplasia of the bone marrow, and patchy discoloration of the skin. Recent research has shown an association between Fanconi anaemia and leukaemia. - Waldenstrom's MacroglobulinemiaThis is a rare malignant condition, involving an excess of beta-lymphocytes (a type of cell in the immune system) which secrete immunoglobulins (a type of antibody). WM usually occurs in people over sixty, but has been detected in younger adults. Internet Resources for Haematological MalignanciesFrench-American-British (FAB) Classification SchemeLeukaemia can be classified using the French-American-British (FAB) criteria. for cell morphology: L1 - ALL: small lymphoid cells, regular nuclei L2 - ALL: large lymphoid cells, irregualr nuclei L3 - ALL: large homogeneous cells with prominent nucleolus M1 - Myeloblastic leukemia without maturation M2 - Myeloblastic leukemia with maturation M3 - Promyelocytic leukemia M4 - Myelomonocytic leukemia M5 - Monocytic leukemia M6 - Erythroleukemia M7 - Megakaryoblastic leukemia M0 - AML with minimal differentiation CNS ProphylaxisLeukaemia can sometimes spread to the spinal cord and brain (Central Nervous System). Intrathecal chemotherapy (injection into the fluid around the spine) may be given to combat or prevent CNS relapse. Blood CountsBlood counts are done to test the number of each of the different kinds of cells in the blood. This may be an aid to diagnosis or done to monitor toxicity after each course of chemotherapy. The next course of chemotherapy may be delayed until white cells, neutrophils, and platelets have recovered to a safe level. CardiotoxicityCardiotoxicity (damage to the heart) is associated with certain anti cancer drugs, especially Adriamycin. As such the total dose of these drugs may be limited to reduce the risk of cardiotoxicity. EchocardiagramAn Echocardiogramis where an image of the heart is formed when high frequency sound waves are reflected from the muscles of the heart. An echocardiogram may be done before treatment starts to establish a baseline from which to compare future tests. Metastases through the cardivascular systemThe network of blood vessels reach all parts of the body and may provide one of the routes for cancer cells to spread to secondary sites. Related Abbreviations and Acronyms
Further Resources (4 links)
SEER, National Cancer Institute WebAnatomy, University of Minnesota Human Anatomy - Heart circulatory
system eDewcate.com The Circulatory SystemPaul Andersen This guide by Simon Cotterill First
created 4th March 1996 How do the cardiovascular system and the respiratory system work together to provide the body with oxygen and dispose of waste products?The circulatory and respiratory systems work together to circulate blood and oxygen throughout the body. Air moves in and out of the lungs through the trachea, bronchi, and bronchioles. Blood moves in and out of the lungs through the pulmonary arteries and veins that connect to the heart.
How does the cardiovascular system and the respiratory system work together?The human cardiovascular system (CVS) and respiratory system (RS) work together in order to supply oxygen (O2) and other substrates needed for metabolism and to remove carbon dioxide (CO2). Global and local control mechanisms act on the CVS in order to adjust blood flow to the different parts of the body.
How do the respiratory system and circulatory system work together in transporting nutrients and wastes to the different parts of the body?Your heart is the only circulatory system organ. Blood goes from the heart to the lungs to get oxygen. The lungs are part of the respiratory system. Your heart then pumps oxygenated blood through arteries to the rest of the body.
How does the cardiovascular system and digestive system work together to deliver nutrients to your body's cells?The heart, blood and blood vessels work together to service the cells of the body. Using the network of arteries, veins and capillaries, blood carries carbon dioxide to the lungs (for exhalation) and picks up oxygen. From the small intestine, the blood gathers food nutrients and delivers them to every cell.
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