Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs (NSAIDs), phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals. Show
Some drugs may cause fixed drug eruption, which is followed by localised hyperpigmentation and gradually fades. Drug-induced pigmentationWhat causes drug-induced skin pigmentation?Several mechanisms may be involved in the drug-induced changes of pigmentation of the skin.
What are the clinical features of drug-induced skin pigmentation?The clinical features of drug-induced skin pigmentation are very variable according to the drug involved. A large range of patterns and shades may be formed.
What is the treatment for drug-induced skin pigmentation?Drug-induced skin pigmentation can become cosmetically disfiguring. In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Laser treatment has been successful in treating amiodarone-induced skin pigmentation. Which assessment findings would indicate cyanosis in individuals with dark skin?In light-skinned patients, cyanosis presents as a dark bluish tint to the skin and mucous membranes (which reflects the bluish tint of unoxygenated hemoglobin). But in dark-skinned patients, cyanosis may present as gray or whitish (not bluish) skin around the mouth, and the conjunctivae may appear gray or bluish.
Which disease condition can be found more in fair skinned patients than in those with more pigmentation in their skin?Skin cancer is more common in fair skinned people because they have less of the protective pigment called melanin. People with darker skin are less likely to get skin cancer.
Which common skin problem might the nurse observe in an older adult patient?Growths such as skin tags, rough patches (keratoses), skin cancers, and other lesions are more common. Older adults may also be less able to sense touch, pressure, vibration, heat, and cold.
What are the two basic factors that interact to produce skin color?Numbers of Melanocytes/ levels of Melanin synthesis. The basic factors interacting to produce skin color are: Circulatory supply and pigment concentration and composition.
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